Mar 09, · Instead high CD31 count was associated with early stage cancer (p = ) and in this subgroup high VEGF expression correlated with poor survival (p = ). Additionally, in early stage cancer Cited by: Dec 05, · Adams J, Carder PJ, Downey S, et al. Vascular endothelial growth factor (VEGF) in breast cancer: Comparison of plasma, serum, and tissue VEGF and microvessel density and effects of tamoxifen. Cancer .
In addition to inducing angiogenesis, vascular endothelial growth factor-A (VEGF-A) is believed to directly increase cancer cell metastatic potential and overexpression of VEGF-A is associated with higher invasiveness of breast cancer. Although the known angiogenic peptides have not been systematically compared, these retrospective studies suggest that VEGF plays a relevant biological role in the progression of breast cancer. Cited by:
BACKGROUND: While vascular endothelial growth factor (VEGF) expression in breast tumors has been correlated with a poor outcome in the pathogenesis of breast cancer, the expression, localization, and function of VEGF receptors VEGFR1 (also known as FLT1) and VEGFR2 (also known as KDR or FLK1), as well as neuropilin 1 (NRP1), in breast cancer. In this study, we demonstrate a novel mechanism for activation of GLI-mediated signaling in epithelial breast tumor cells via EMT cell-induced production and secretion of VEGF-C. We show that VEGF-C, secreted by breast cancer cells that have undergone an EMT, promotes paracrine-mediated increases in proliferation, migration, and invasion of epithelial breast cancer cells Author: Deguang Kong, Deguang Kong, Hengbo Zhou, Deepika Neelakantan, Connor J Hughes, Jessica Y Hsu, Ramakr.
Breast cancer is the most common cancer in females and the leading cause of cancer death in women worldwide. Angiogenesis, the formation of new blood vessels, plays an important role in the development and progression of breast cancer Cited by: Expression Levels of Ki and VEGF in Breast Cancer. VEGF has been recognized as playing a role in breast cancer progression. 11 VEGF expression in breast cancer is well documented and is produced by both macrophages and cancer cells in breast carcinoma. 12 VEGF receptor expression has also been observed on breast cancer .
The assessment of angiogenesis in breast cancer is of importance as a key indicator of survival and response to therapy. Circulating vascular endothelial growth factor (VEGF) measurements may Cited by: Immunohistochemical analysis of expression of VEGF, estrogen (ER) and progesterone receptor (PR), HER-2/neu, and Ki67 was performed in breast cancers. VEGF expression estimated .